Relation between administered dose and biological effect; typically sigmoidal E = E_max · C^n/(EC₅₀^n + C^n) (Hill). Threshold-vs-no-threshold distinction critical for carcinogens (linear no-threshold LNT) versus non-cancer endpoints.
Relation between administered dose and biological effect; typically sigmoidal E = E_max · C^n/(EC₅₀^n + C^n) (Hill). Threshold-vs-no-threshold distinction critical for carcinogens (linear no-threshold LNT) versus non-cancer endpoints.